RFI for Artificial Intelligence-Enabled Discovery of Broad-Spectrum Small-Molecule Inhibitors for Filoviruses Service

The Defense Threat Reduction Agency is conducting market research to identify organizations with capabilities in artificial intelligence for application in the discovery and advancement of broad-spectrum, small-molecule therapeutics targeting filoviruses. The agency is seeking to solve the challenge of identifying effective therapeutic candidates against these viral threats by leveraging advanced computational technologies. The requested scope of work covers artificial intelligence-driven design, in vitro verification of identified hits, and early preclinical proof-of-concept evaluation. All performance of the work will take place offsite at the selected organization's facilities. Eligible participating organizations must be onshore United States entities. The agency is currently looking for proposals to establish budget parameters and has not disclosed a pre-determined funding limit. Key dates and specific evaluation criteria are not detailed in this initial market research request.