Real-Time Pathogen Host Interactome Prediction Service

The government authority located in Washington, DC is seeking a real-time pathogen host interactome prediction service. The agency needs to rapidly characterize host-pathogen interactions from pathogen protein sequence alone to enable timely medical countermeasure prioritization and force health protection against novel or emerging biological threats. This operationally deployable capability must characterize any pathogen that is naturally emerging, accidentally released, or engineered. The scope of work requires predicting host-pathogen protein interactions with high accuracy across viral, bacterial, and parasitic pathogen classes. The service must demonstrate zero-shot prediction capability on previously unseen pathogens. Additionally, the agency requires comprehensive functional annotation of both pathogen and host proteins alongside automated analysis that generates ranked mechanistic hypotheses about infection pathways. Eligibility is restricted to onshore United States organizations only. The agency expects the performance of the work to take place offsite. The authority is currently looking for proposals to determine the budget, and specific evaluation criteria and key dates are not provided in the source.