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Non-Optical Methods for High Speed Protein Control

Federal · Dept of DefenseDue Thursday, December 31, 2026
Client
Dept of Defense
RFP Number
—
Posted
—
Category
US Federal
Budget
—
NAICS
541714
Set-aside
—
Contact
Dr. Jeffrey Zaleski, DARPA/BTO
Email
[email protected]

Description

AI Generated

The Defense Advanced Research Projects Agency (DARPA) BTO seeks innovative, post-competitive, awardable solutions for a new class of rapidly switchable, non-optogenetic protein domains. The buyer needs a robust and versatile molecular tool for massless information transfer across a cell membrane to supplement existing synthetic biology platforms. The scope involves developing non-optical methods for high-speed protein control. No specific eligibility, evaluation, budget, or key-date details are provided in the source description.

Key solicitation details

AI-extracted from DARPA-SN-26-89-Amendment-01.pdf. Confirm against the original documents before bidding.

The Department of Defense, DARPA BTO, is seeking innovative, post-competitive solutions for a new class of rapidly switchable, non-optogenetic protein domains for real-time cellular control. The effort aims to develop a versatile molecular tool for massless information transfer across a cell membrane to supplement existing synthetic biology platforms. Submissions are solicited through the ERIS Marketplace.

Issued by
Department of Defense
Notice Dates
June 8, 2026 – December 31, 2026
How to submit
ERIS Marketplace
Submission details
DARPA BTO will actively shop the ERIS Marketplace for solutions.

Scope of work

  • Develop a new class of rapidly switchable, non-optogenetic protein domains for real-time cellular control
  • Develop a robust and versatile molecular tool for massless information transfer across a cell membrane

Official SAM.gov notice

Solicitation number
DARPA-SN-26-89
Agency
Department of Defense
Buying office
Defense Advanced Research Projects Agency (Darpa) › DEF Advanced Research Projects Agcy
Notice type
Special Notice
Responses due
Dec 31, 2026, 11:59 PM ET
Posted on SAM.gov
Jul 21, 2026
NAICS
541714 · Research and Development in Biotechnology (except Nanobiotechnology)
Product/service code
AC12
Contracting contact
Dr. Jeffrey Zaleski, DARPA/BTO
[email protected]
Read the official notice description

UPDATE: The purpose of Amendment 1 to DARPA-SN-26-89, the Non-Optical Methods for High Speed Protein Control Special Notice (SN), is to clarify the notice deadline. DARPA BTO will be actively “shopping” the ERIS Marketplace for innovative, post-competitive, awardable solutions that address the need for a new class of rapidly switchable, non-optogenetic protein domains for real-time cellular control. This effort seeks to develop a robust and versatile molecular tool for massless information transfer across a cell membrane, intended to supplement existing synthetic biology platforms.

Source: SAM.gov contract opportunities data (U.S. federal public data).

Incumbent

No incumbent history found for this requirement. The notice does not cite a current contract, and no earlier award from this buying office matches it.

Market context

Awards in the same category (Research and Development in Biotechnology (except Nanobiotechnology)). This is not this requirement's award history.

Recent similar awards: Department of Defense, NAICS 541714

Vendor and awardValueEnds
DUKE UNIVERSITYN0002425C4322 · RESEARCH STUDY$700.1KFeb 23, 2030
L3 TECHNOLOGIES, INC.N0001924C0061 · NGJ LB CB1 DEVELOPMENT$265.1MAug 24, 2029
THE BOEING COMPANYHQ014719C0004 · GBI/AUR PROGRAM MANAGEMENT/SYSTEMS ENG$4.4BMar 31, 2029
INTRALYTIX INCW911QY25C0015 · BROAD AGENCY ANNOUNCEMENT TO HAVE STABLE DRY FORMULATION OF A SAFE PHAGE PREPARATION THAT $178.8KFeb 19, 2029
GENERAL DYNAMICS INFORMATION TECHNOLOGY, INC.FA238425CB045 · BIO-EFFECTS RESEARCH OF DIRECT ENERGY EXPOSURE$8.8MJan 26, 2029

Top vendors in this category: Department of Defense, NAICS 541714, since Oct 1, 2023

558 contract awards in this NAICS over the period.

  1. 1. THE BOEING COMPANY$324.8M
  2. 2. L3 TECHNOLOGIES, INC.$265.1M
  3. 3. SNA INTERNATIONAL LLC$48.3M
  4. 4. APPLIED RESEARCH ASSOCIATES, INC.$47.6M
  5. 5. LEIDOS, INC.$46.8M

Source: USAspending.gov federal award data (U.S. federal public data). A contract is called the incumbent only when the notice or its documents cite it by number.

Source and verification

Original source

Craxy AI summarizes this opportunity from the original listing and available solicitation documents. Confirm submission instructions and amendments with the issuing source before responding.

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